TDK conference 2011

Based on literary sources, the number of spontaneously occurring tumors in Guinea pigs is relatively low. Similarly, scant information is available regarding the histological background of the tumors. Over the course of our research, we had analyzed the histological makeup, frequency and distribution of tumors in Guinea pigs. The subject matter of the study was composed of pathological changes that were classified as tumors by means of macroscopic examination, sent to the Department of Pathology and Forensic Veterinary Medicine of Szent István University. The submitted tissue samples were preserved in formalin. The classification of the samples was performed with the aid of optical microscopy. In spite of the assumed macroscopic diagnosis, of the 59 submitted samples, histological examination revealed that 18 of them were not tumors, being so called pseudo-tumors. Among the actual tumors, we have found large numbers of epithelial tissue based adenomas, trichofolliculomas, lipomas growing from mesenchyma and in insignificant numbers mixed tumors of various composition. Most pathological changes affected animals aged 2, 4 and 5, which matches literary sources, meaning that under the age of 1, tumors are extremely rare in this species. There were no detectable significant differences between genders. From a differentiation perspective, the bulk of the examined population contained typical, so-called benign tumors.