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Home » Archive » 2013

TDK conference 2013

Prognostic and diagnostic values of whole blood Prothrombin Time determination in colic horses
Schwahofer Anna - year 6
SzIU, Faculty of Veterinary Science, Üllő, Large Animal Clinic
Supervisors: Kata Wirth DVM, Csaba Árpád Bajcsy DVM

Abstract:

Gastrointestinal colic could be concluded in sepsis and/or disseminated intravascular coagulation, thus coagulation parameters (Prothrombin Time /PT/, activated Partial Thromboplastin Time /aPTT/, etc.) could have diagnostic and/or prognostic value. Usability of a whole blood coagulation analyzer was tested, because in the case of equine colic currently, there are no widely accepted and applied laboratory tests available, which may support veterinary decisions. Developing and evaluating a simple near-patient test could support more adequate decisions and interventions.

Jugular venous blood from 50 colic and 10 non-colic horses were taken once daily. 14 horses unterwent surgery (surgical cases), and 32 were treated conservatively (medical cases). In the surgical cases hemostasis tests were performed during an observation period, before, during and after surgery and during the postoperative period. In the medical cases and non-colic, healthy animals hemostasis tests were performed when admitting the anamnesis and during the days of hospitalization ( in non-colic, healthy animals always for 5 consecutive days).

The coagulation measurements showed high differentiation power on the severity of the illness, especially when fatal cases were compared to less severe surgical or medical cases. Whole blood PT values of surgically treated horses significantly differed from the values of the conservatively treated animals (in average 160 % and 116 % of the physiological value, respectively).

Plotting whole blood PT values measured during the first 24 hours of the treatment showed significant difference between the surgically and conservatively treated groups. In horses with severe colic signs PT continuously increased exceeding 300 % of the physiological value, while PT in conservatively treated horses declined to normal values or to a slightly elevated level (at maximum 130 %). Plasma PT showed no significant differences among the different cohorts.

After completion such studies with supporting results a more professional system of colic prognosis could be developed for horses and incorporated into the measuring instrumentation making veterinary decisions easier and more accurate.

Study was supported by Diagon Ltd.



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