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Home » Archive » 2013

TDK conference 2013

Investigation of canine myofibroblastic tumour with immunohistochemistry
Ambrus Ádám - year 4
SzIU, Faculty of Veterinary Science, Department of Pathology and Forensic Veterinary Medicine
Supervisor: Jakab Csaba DVM

Abstract:

The inflammatory myofibroblastic tumour is a special mesenchymal neoplasm which features proliferation of elongated (spool shaped) cells and infiltrated inflammatory cells. Pathohistologic research based on eosin and haematoxylin showed mostly chronic inflammatory process followed by angiofibroblast tissue proliferation however immunohistochemistric investigations revealed myofibroblastic parenchyma along with low grade biologic characteristics for malignacy. Earlier it was registered as plasma cell granuloma, inflammatory pseudotumour, inflammatory myofibrohistiocytic proliferation, or inflammatory fibrosarcoma. During our work we examined bioptates of dogs which seemed to be chronic fibrohistiocytic inflammation. We made further immunohistochemistric research with the following antibodies: anti-vimentin, alpha-smooth muscle actin, S-100 protein, c-Kit, lysosyme, PCNA, Ki-67, claudin-5. As a result we detected myofibroblastic neoplasm which is presented the first time in the domestic veterinary diagnostics.



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