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Home » Archive » 2015

TDK conference 2015

Prognostic value of serum pancreatic and hepatic enzyme activity in horses with duodenitis-proximal jejunitis
Farkasová Lúcia - year 5
SzIU, Faculty of Veterinary Science, Department and Clinic of Equine Medicine
Supervisor: Tóth Balázs DVM

Abstract:

Duodenitis-proximal jejunitis (DPJ) is a sporadic, severe and acute disease of horses

involving the proximal part of the small intestine. The etiology of the DPJ remains incompletely understood. Lesions are usually confined to the proximal half of the small intestine, including the duodenum, variable length and location of jejunum, sometimes the pylorus and it may be associated with varying severity of colic and fever. Gastric reflux, consequential heamoconcentration, hypovolaemia, electrolyte disorders and functional organ dysfunctions may also be noted. The acute inflammation and the abnormal intestinal permeabilty leads to endotoxaemia as well as leukopenia is also common in DPJ. Beside systemic complications, ascending cholangiohepatitis caused by duodenal dysfunction has been anecdotally documented. The prognosis of the disease is considered good in case of intense hospitalization, but the influential facts of survival are unknown. Previous reports of DPJ haven‘t investigated histopathologic changes of the pancreas, but based on the authors experiences the increased activity of serum amilase and lipase can be associated with the fact that the exocrin part of the pancreas is affected via asceding insult.

The aim of the following study is to define prognostic parameters of the horses diagnosed with DPJ; analyzing the coherence between the activity of serum pancreatic and hepatic enzymes and the survival rates. Our hypothesis was that there‘s a negative correlation between increased activity of the serum pancreatic enzymes and survival.

The data collection of this retrospective analysis is based on cases acquired from Department and Clinic of Equine Medicine. The medical records of 45 horses with DPJ were reviewed from 2007 to 2015. Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamile transferase (GGT), glutamate dehydrogenase (GLDH), amilase and lipase serum activities were collected and analyzed from the results performed at the admission. Furthermore, anamnesis, clinical and clinicopathological findings, treatments, complications and survival rates were collected. Data were analyzed by descriptive statistics as well as by Fisher-test, Chi-Square test and Mann-Whitney U test. Significantly increased differences were revealed in the following parameters: heart rate (p=0.005), capillary refill time (p=0.003), abdominal fluid total protein concentration (p=0.001), lipase (p=0.007), amilase (p=0.006) and AST (p=0.001).

The results of our study support that cardiovascular status of the admitted DPJ cases similarly to other gastrointestinal diseases, in addition to hepatic and pancreatic involvement can be of prognostic significance of survival. However, further clinical studies are warranted to further support this notion.



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