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Home » Archive » 2015

TDK conference 2015

Investigation of idiopathic intestinal adenocarcinoma in captive-bred rainbow trout
Hoitsy Márton György2 - year 5
SzIU Faculty of Veterinary Science, Department of Pathology
Supervisors: Ferenc Baska DVM, Csaba Jakab DVM

Abstract:

Rainbow trout (Oncorhynchus mykiss, Walbaum) is one of the most commonly bred fish species in Europe, which plays an important role in the gastronomy. The brood stock has a significant value at the farms, therefore the prevention of illnesses is crucial.

During our research we investigated an idiopathic intestinal tumor in rainbow trout. All the examined individuals were 3-6 years old, as tumors need a longer period to develop and therefore cannot be found in fingerlings, summerlings and consumable fish. The healthcare of the valuable broodfish is of great importance in fish farms. Nowadays, the investigation of tumors growing in trouts is considered a pioneering field of research.

During the necropsy, tumors found on the gills and in the intestines of broodfish were identified with the help of histological and immunohistochemical tests.

The primary adenocarcinoma developed in the small intestine. The malignant tumor tissue with a high mitotic index infiltrated and broke through the basal membrane and the propria, and spread asymmetrical to the cross-section of the intestine narrowing the lumen of the intestine causing the passage disorder of the intestinal contents and emaciation among the fish. The primary tumor formed metastases in the vessels of the gill in all cases, which were also found in the middle and peripheral part of the primary lamellae, resulting in respiratory disorder. In some cases the tumor led to invagination in the lumen of the intestine and consequential ileus. These animals died soon.

The intestinal carcinoma of the trout gave positive results to pan-cytokeratin and E-cadherin in immunohistochemical tests, the peritumoral endothel cells also showed claudin-5- positivity. The other tests with anti-vimentin, anti-alfa-smooth muscle actin, anti-S-100 protein, anti-NSE antibody led to negative results.

Further studies are planned to investigate the potential pathogens, substances and effects that cause the tumors.



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