Students' Research Circle    
 
 
2022
2021
» 2020
Call for papers
The conference
Veterinary Session
Veterinary Jury
Sponsors
Awards-list
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
Home » Archive » 2020

TDK conference 2020

The effect of spermidine on the aging hippocampus
Juhász Péter - year 3
University of Veterinary Medicine Budapest, Department of Anatomy and Histology
Supervisor: Dr. Bence Rácz

Abstract:

Due to the recent advance in modern medicine, the average age of the human population has increased significantly, however, learning and cognitive disabilities are common negative factors among symptoms in the aged population. One pivotal factor in the obvious decline in cognitive function during aging is presumed to be the reduced synthesis of endogenous polyamines in the nervous system. The production of spermidine – an aliphatic polyamine – is also being reduced during aging, but its exogenous administration by food seems to be effective in relieving multiple signs of dementia. After absorption, spermidine can pass the blood–brain barrier and exert its neuroprotective effects. In this study we used quantitative transmission electron-microscopy of the hippocampal region of mice divided into three groups: young, old-aged and old spermidine supplemented.The hippocampus plays an essential role in many aspects of cognitive functions, including learning and memory. Besides analyzing the synaptic neuropil, we also focused on the density, shape and size of mitochondria in the neuropil, and compared the three groups. We found that spermidine helped to restore synaptic features in aged animals, and also the number of mitochondria, which was significantly decreased in old animals, compared to young ones. Taken together our result strongly suggest, that supplementation can be effectively used to slow cognitive decline caused by aging.



List of lectures