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Veterinary sessionRothensteiner Johanna - year 6 University of Veterinary Medicine Budapest, Department and Clinic of Equine Medicine Supervisors: Dr. Tóth József, Dr. Makra Zita The ocular and periocular squamous cell carcinoma (SCC) is a slowly growing tumour. It is the second most common neoplasm in equines, and the most common in the eye and adnexa. Metastasis is rarely recognized and is only in severe cases detectable. The growth starts in plaques and epithelhyperplasia. The typical shape is cauliflower like. The pathogenesis is not cleared yet, but genetic predisposition, periocular depigmentation, age, ultraviolet light of solar radiation, viral infection and hormonal status influence the appearance of SCC. Different therapies are preformed depending on the location, size, invasiveness, and shape of the neoplasm. Usually a combination of different treatment possibilities are used to decrease the recurrence rate. Surgical removal, cryotherapy, high frequency hyperthermia, beta-radiation with Strontium 90, gamma- radiation with Iridium 192, laser ablation with carbon-dioxide, Bacillus Calmette-Guerin vaccine and topical treatment with Mitomycin C is described for the therapy of SCC. This study includes 126 equine patients of a German Equine Hospital (“Tierärztliches Kompetenzzentrum Karthaus GmbH, Abteilung Augenheilkunde”). The retrospective study reports different ocular SCC cases and their treatment possibilities to compare surgical removal and adjunctive therapies. The dataset was split in two groups: group of horses treated with and without Mitomycin C. Data were analysed and compared regarding the age, breed, location, cytology, and recurrence using descriptive statistics. Minimum, maximum, and mean age of the patients were 3, 38 and 16,26 years of age. Most common breed was the Haflinger (55,6%). Unilateral tumour growth was mostly detected in 91,2% of the cases. Cornea and conjunctiva were affected in 32,53% of the cases. Majority of the cases (78%) was confirmed microscopically, each one horse additionally with blastoma, adenocarcinoma, or basosquamous SCC was detected. Recurrence rate was 25,4%. In the group of Mitomycin treated patients had a minimum, maximum, and mean age was: 4, 38, and 15 years of age, respectively. 63,49% of them were Haflinger and most common site was cornea and conjunctiva. (34,92%). Recurrence rate was 27%. Horses treated without Mitomycin C had a minimum, maximum, and mean age was 3, 29, and 17,5 years. 47,6% were Haflinger. Overrepresented location was the cornea and conjunctiva. (25,39%) The recurrence rate was 23,8%. As a conclusion our results show that mitomycin C as a single therapy in the majority of horses at an early stage can support healing and does not lead to tumour recurrence. As single therapy it may be used in smaller sized abnormalities and early detected plaques. We used primarily surgery then Mitomycin C treatment topically, but this combination did not show significant difference between the two groups. List of lectures |