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» Veterinary Session
Veterinary sessionMc Grath Lucy Mary - year 6 University of Veterinary Medicine Budapest, Department of Microbiology and Infectious Diseases Supervisor: Gergely Tóth Bovine respiratory disease complex (BRDC) is one of the most common and costly disease in cattle production worldwide. The multifactorial nature of BRDC necessitates comprehensive research and targeted strategies for prevention, including identification and serotyping of prevalent strains and vaccination combined with improved management practices, to mitigate its impact on cattle health and productivity. The last major serological examination of Mannheimia haemolytica and Biberstenia trehalosi in Hungarian cattle was published twenty-four years ago, highlighting the timeliness and relevance of undertaking this research again. Over a period of six years (2017-2023), a total of 72 M. haemolytica 2 M. glucosida and 8 B. trehalosi strains were isolated from cattle presenting with clinical signs of BRDC in Hungary. The isolates were serotyped using passive hemagglutination. The identification of the strains on species level was confirmed by PCR. With regards to M. haemolytica this study identified a predominance of serotypes A2 (43.1%, 31/72), A1 (41.7%, 30/72), and A6 (11.1%, 8/72). 2.8% (2/72) of the isolates were classified as A16 and there was one non typable isolate (1.3%, 1/72). Two isolates represented serotype A11 also known as M. Glucosida. With regards to Biberstenia trehalosi, 75% (6/8) of the isolates represented T4 while T15 was present as 12.5% (1/8) of the isolates. One strain was non typable (12.5%, 1/8). The findings of this study offer valuable insights into the prevalence of serotypes associated with pneumonic pasteurellosis in Hungarian cattle. Based on these findings, contrary to previous beliefs, but in accordance with the previous Hungarian data, M. haemolytica serotype A2 and B. trehalosi serotype T4 may be considered as primary pathogens of respiratory disease in cattle and should be investigated further. Furthermore, this study brings to the forefront the limitation of current commercial vaccines, which mainly contain only the M. haemolytica serotype A1, and provide serotype-specific protection, therefore, do not offer comprehensive protection against M. haemolytica and B. trehalosi. A comprehensive understanding of the prevalence of these organisms and their serotypes informs a focused strategy for the manufacture of vaccines against BRDC. List of lectures |