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The effects of the nutritional composition on dogs in an experimental pancreatitis model
Vad Petra - year 5
University of Veterinary Medicine Budapest, Department of Internal Medicine
Supervisors: Dr. Eszter Tünde Kanyorszky, Dr. Ágnes Sterczer

Abstract:

Acute pancreatitis in dogs is considered to be idiopathic, however its development might be caused by underlying predisposing factors. The course of the disease ranges from mild to severe and it can even be fatal. Timely beginning of the treatment is essential for a favourable prognosis. Based on previous studies, it can be concluded that in case of acute pancreatitis food deprivation is unbeneficial, because it is indispensable to provide nourishment to the patients. Enteral feeding was proved to be the more effective nutritional method compared to parenteral feeding. Nonetheless, it was yet to be examined how the ingredients and the fat content of the feed used during enteral feeding affects the outcome of the illness.

In our study, we have induced pancreatitis in ten dogs using cerulein and divided them into two groups of five. One group was fed with high-fat (0.15g/ml), while the other with low-fat (0.02g/ml) food for eight days with the two types of food having the same energy content: glucose in the low-fat food, and lipid infusion in the high-fat food provided the appropriate energy level. Following a physical examination and the collection of blood samples on the first day of the experiment, the dogs were given a dose of cerulein every hour within the next six hours. After the first and the last cerulein injection an abdominal ultrasound scan was performed, in order to detect any sign of pancreatitis. From the second day on, every dog has received the same treatment: physical examination, blood sampling, feeding through a naso-oesophageal feeding tube, pain and vomiting relief, infusion treatment and antibiotic therapy. In order to monitor the lesions on the pancreas and its surrounding, an ultrasound scan was performed on each dog on the third and the seventh day. On the fifth and sixth day an additional cerulein injection was administered, as their condition has improved significantly based on their blood test results due to the immediate treatment of the pancreatitis. On the ninth day, after ending the experiment, the dogs were euthanized and their organs were examined pathologically and histologically.

The evaluation of the collected data shows no statistically significant differences between the two groups, however the blood tests and the ultrasound scans suggest that during the therapy of acute pancreatitis low-fat nutrition is more suitable for enteral feeding than high-fat nutrition.



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