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Home » Archive » 2014

TDK conference 2014

Examination of the nephrotoxiticy of selected NSAIDs in broilers and pigeons
Fehér Judit - year 5
SzIU, Faculty of Veterinary Science, Department of Pharmacology and Toxicology
Supervisor: dr. György Csikó

Abstract:

The non-steroidal anti-inflammatory drugs (NSAIDs) are regularly used both in human and in veterinary practice their side effects are well known in mammalians and several studies investigated those of possible toxic effects. There are very limited data available about the use of NSAIDs in avian species. The lack of data on avian species difference in NSAID sensitivity justifies our study in which the nephrotoxic effect of diclofenac and acetylsalicylic acid were compared in chicken and pigeon. The aim of our experiments was to investigate the impact of the species sensitivity on the nephrotoxic effect of these two NSAIDs used in clinical practice. Sixteen five week old Broiler chickens and sixteen 3 to 12 month old pigeons were treated for three days after a week of acclimatization period. The birds were divided into 4-4 groups; controls, low dose (5 mg/kg bw.) and high dose (50 mg/kg bw.) diclofenac and acetylsalicylic acid (50 mg/kg bw.) groups. At the day before and at the day of treatment the birds were thirsted for sensitization. The application of both diclofenac doses caused serious damage in broilers of which most of them died after the first or the second exposure. The cause of death was serious visceral gout. The low dose diclofenac was well tolerated in pigeon and the acetylsalicylic acid in both species. Blood samples were taken for biochemical analyses one day after the third administration from all survived animals which were thereafter humanely euthanized and dissected. Renal tissues for histopathological examination were collected from each animal. Necrotic index was calculated to compare the degree of lesions using the histological sections thus we can get a more accurate picture of the nephrotoxic effect of the applied drugs.



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